Datopotamab deruxtecan

MCE 国际站：Datopotamab deruxtecan

CAS：2238831-60-0

品牌：MedChemExpress (MCE)

存储条件：Please store the product under the recommended conditions in the Certificate of Analysis.

生物活性：Datopotamab deruxtecan (DS-1062; Dato-DXd) 是一种滋养层细胞表面抗原 2 (TROP2) 导向的抗体活性分子偶联物 (ADC)。Datopotamab deruxtecan 具有强大的抗肿瘤活性。

体外：Datopotamab deruxtecan (Dato-DXd; 100 μg/mL) binds specifically to TROP2 and was internalized into tumor cells followed by intracellular trafficking to lysosome and Deruxtecan release, which induced DNA damage and apoptosis in TROP2-expressing tumor cells in vitro
[1]. MCE has not independently confirmed the accuracy of these methods. They are for reference only.

体内：Datopotamab deruxtecan (Dato-DXd; 6 mg/kg) shows potent antitumor activity with tumor regression in several TROP2-expressing xenograft tumors including NSCLC patient-derived xenograft (PDX) models. Safety profiles of Datopotamab deruxtecan in rats and cynomolgus monkeys are acceptable
[1]. MCE has not independently confirmed the accuracy of these methods. They are for reference only. Clinical Trial

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研究领域：Antibody-drug Conjugate/ADC Related|Cell Cycle/DNA Damage

作用靶点：Antibody-Drug Conjugates (ADCs)|Topoisomerase

热门产品线：重组蛋白 | 化合物库 | 天然产物 | 荧光染料 | PROTAC | 同位素标记物 | 寡核苷酸

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参考文献：
[1]. Daisuke Okajima, et al. Datopotamab Deruxtecan, a Novel TROP2-directed Antibody-drug Conjugate, Demonstrates Potent Antitumor Activity by Efficient Drug Delivery to Tumor Cells. Mol Cancer Ther. 2021 Aug 19.

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